Anti-IL-6 Antibody [MP5-20F3] (A281251)

Anti-IL-6 Antibody [MP5-20F3]

Rat anti Mouse Interleukin-6

Rat anti Mouse Interleukin-6 antibody, clone MP5-20F3 recognizes mouse Interleukin 6 (IL-6), also known as B-cell hybridoma growth factor or Interleukin HP-1. IL-6 is a potent lymphoid cell growth factor principally expressed by macrophages and T-cells. IL-6 is a potent inducer of the acute phase response.Animals lacking IL-6 demonstrate a marked reduction in the production of proinflammatory Th17 cells (Ivanov et al. 2006). In humans disruption of the IL-6 gene may lead to the presentation of rheumatoid arthritis systemic juvenile (RASJ), an inflammatory articular disorder manifesting with daily spiking fever, macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.Rat anti Mouse Interleukin-6 antibody, clone MP5-20F3 may be used to neutralize IL-6 bioactivity in a functional assay (Abrams et al. 1992 and Kambayashi et al. 1995).

Mouse

Recombinant murine IL-6.

Rat

Monoclonal

IgG1

Protein G chromatography.

500 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

B-cell stimulatory factor 2, BSF-2, CDF, CTL differentiation factor, Hybridoma growth factor, IFN-beta-2, IFNB2, IL6, Interferon beta-2, Interleukin-6