Anti-IL-6R Antibody [B-R6] (A279851)

Anti-IL-6R Antibody [B-R6]

Mouse monoclonal [B-R6] antibody to IL-6R.

This antibody recognises human Interleukin-6 receptor subunit alpha, also known as CD126, IL-6R or Membrane glycoprotein 80. Human CD126 is a 468 amino acid single pass type I transmembrane glycoprotein bearing a single Ig-like C2 type domain, two fibronectin type III domains and a single WSXWS motif which may be involved in receptor activation. recognises both the soluble and membranous human CD126Removal of sodium azide is recommended prior to use in functional assays.

ELISA, IF, Flow Cytometry, IHC-Fr, IP

Flow Cytometry: 1:50, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Human

CHO cells transfected with cDNA of the IL-6 receptor.

Mouse

Monoclonal

B-R6

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CD126 antibody, clone B-R6 recognizes human Interleukin-6 receptor subunit alpha, also known as CD126, IL-6R or Membrane glycoprotein 80. Human CD126 is a 468 amino acid single pass type I transmembrane glycoprotein bearing a single Ig-like C2 type domain, two fibronectin type III domains and a single WSXWS motif which may be involved in receptor activation (Daqil et al. 2012).Mouse anti Human CD126 antibody, clone B-R6 inhibits IL-6 mediated proliferation of XG-1 cells (Lu et al. 1995) and partially blocks binding of IL-6 to its receptor (Fourcin et al. 1994), clone B-R6 recognizes both the soluble and membranous human CD126Removal of sodium azide is recommended prior to use in functional assays.