Recombinant Anti-Insulin Receptor alpha Antibody [INSR/2277R] (A249047)

Anti-Insulin Receptor alpha Antibody [INSR/2277R]

Recombinant rabbit monoclonal [INSR/2277R] antibody to Insulin Receptor alpha.

The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment from the extracellular domain of human Insulin Receptor alpha. The exact sequence is proprietary.

Rabbit

Monoclonal

INSR/2277R

IgG

Protein A/G chromatography.

200 µg/ml

135 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Insulin Receptor alpha Antibody [INSR/2277R] - BSA and Azide free (A252227).