Anti-Interferon beta Antibody [C06-4F6] (Biotin) (A279938)

Anti-Interferon beta Antibody [C06-4F6] (Biotin)

Mouse monoclonal [C06-4F6] antibody to Interferon beta (Biotin).

This antibody recognises interferon beta (IFN beta) also known as fibroblast interferon, a type I interferon. It is constitutively expressed, but is synthesized at a higher level upon infection. IFN beta plays many roles within inflammation including limiting the immune response during inflammation through induction of IL-10 and can inhibit the inflammasome and IL-1 beta. It can also play a role in the reprogramming of macrophages to an inflammatory and pro-resolving phenotype. These responses are mediated through its interaction with the IFN alpha/beta receptor with subsequent downstream activation of STAT1, 2 or 3. Beyond inflammation IFN beta has been observed to block cancer progression by reducing the recruitment of pro-angiogenic neutrophils into tumors. The biotinylated Mouse anti Human IFN beta antibody, clone C06-4F6 (MCA6237B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human IFN beta antibody, clone F03-2G4 (MCA6236GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length IFN beta (Met22-Asn187).

Mouse

Monoclonal

C06-4F6

IgG2a

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human IFN beta antibody, clone C06-4F6, recognizes interferon beta (IFN beta) also known as fibroblast interferon, a type I interferon. It is constitutively expressed, but is synthesized at a higher level upon infection (Takaoka & Taniguchi 2003). IFN beta plays many roles within inflammation including limiting the immune response during inflammation through induction of IL-10 and can inhibit the inflammasome and IL-1 beta. It can also play a role in the reprogramming of macrophages to an inflammatory and pro-resolving phenotype (Satyanarayanan et al. 2019). These responses are mediated through its interaction with the IFN alpha/beta receptor with subsequent downstream activation of STAT1, 2 or 3 (Takaoka & Taniguchi 2003). Beyond inflammation IFN beta has been observed to block cancer progression by reducing the recruitment of pro-angiogenic neutrophils into tumors (Andzinski et al. 2015).The biotinylated Mouse anti Human IFN beta antibody, clone C06-4F6 (MCA6237B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human IFN beta antibody, clone F03-2G4 (MCA6236GA) as the capture antibody.

Fibroblast interferon, IFB, IFN-beta, IFNB, IFNB1

This product is for research use only. It is not intended for diagnostic or therapeutic use.