Anti-IRS2 Antibody [G01-8F7] (A320295)

Anti-IRS2 Antibody [G01-8F7]

Mouse monoclonal [G01-8F7] antibody to IRS2.

This antibody recognises insulin receptor substrate 2.IRS2 is a cytoplasmic signaling molecule. IRS2 along with IRS1, is a key target of the insulin receptor tyrosine kinase. Serine/threonine phosphorylation of IRS2 has been shown to regulate insulin sensitivity, suggesting that it is required for hormonal control of metabolism. Reduced expression of IRS2 has been shown to result in type 2 diabetes and reduced brain mass in mice (Lin et al. 2004, Schubert et al. 2003)

WB: 1:500

Human

E. coli derived recombinant protein corresponding to amino acids 1035-1338 of human IRS2.

PPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVAATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEPPTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVREEPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTYASIDFLSHHLKEATIVKE

Mouse

Monoclonal

G01-8F7

IgG1

Protein G affinity chromatography of tissue culture supernatant.

1 mg/ml

180 kDa in THP-1 cell lysates

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti human IRS2 antibody, clone G01-8F7 recognizes insulin receptor substrate 2.IRS2 is a cytoplasmic signaling molecule. IRS2 along with IRS1, is a key target of the insulin receptor tyrosine kinase. Serine/threonine phosphorylation of IRS2 has been shown to regulate insulin sensitivity, suggesting that it is required for hormonal control of metabolism (Copps and White, 2012). Reduced expression of IRS2 has been shown to result in type 2 diabetes and reduced brain mass in mice (Lin et al. 2004, Schubert et al. 2003)

Insulin receptor substrate 2, IRS-2