Anti-KDM4B / JMJD2B Antibody (A320150)

Anti-KDM4B / JMJD2B Antibody

Rabbit polyclonal antibody to KDM4B / JMJD2B.

This antibody recognises lysine-specific demethylase 4B, also known as JMJD2B.KDM4B is a member of the alpha-ketoglutarate-dependent hydroxylase superfamily of enzymes. Alpha-ketoglutarate-dependent hydroxylases catalyse a wide range of reactions, including hydroxylation, demethylation and desaturation (Flashman and Schofield, 2007, Hausinger, 2004). KDM4B functions as a histone demethylase and is involved in the regulation of endothelial-to-mesenchymal transition. KDM4B also forms a complex with MLL2 and acts as a co-factor of ERa-mediated transcription.

IP, IF, WB

IF: 1:2,000, IP: 10 µl per IP, WB: 1:500 - 1:1,000

Human

A peptide derived from within the C-terminus of human KDM4B.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human KDM4B antibody recognizes lysine-specific demethylase 4B, also known as JMJD2B.KDM4B is a member of thealpha-ketoglutarate-dependent hydroxylasesuperfamily of enzymes. Alpha-ketoglutarate-dependent hydroxylasescatalyse a wide range of reactions, including hydroxylation, demethylation and desaturation (Flashman and Schofield, 2007, Hausinger, 2004). KDM4B functions as a histone demethylase and is involved in the regulation of endothelial-to-mesenchymal transition (Glaser et al. 2020). KDM4B also forms a complex with MLL2 and acts as a co-factor of ERa-mediated transcription (Kawazu et al. 2011).

JHDM3B, JmjC domain-containing histone demethylation protein 3B, JMJD2B, Jumonji domain containing 2B, Jumonji domain containing protein 2B, Jumonji domain-containing protein 2B, Kdm4b, KDM4B_HUMAN, KIAA0876, Lysine (K) specific demethylase 4B, Lysine demethylase 4B, Lysine-specific demethylase 4B, TDRD14B, Tudor domain containing 14B