Anti-LIMK2 (phospho Thr505) Antibody (A283640)

Anti-LIMK2 (phospho Thr505) Antibody

Rabbit polyclonal antibody to LIMK2 (phospho Thr505).

This antibody recognises LIM domain kinase 2 (LIMK2), when phosphorylated at threonine 505. LIMK2 is a member of the serine/threonine protein kinase family involved in the regulation of actin cytoskeleton reorganization. LIMK2 is phosphorylated at threonine 505 by Cdc42/Rac-PAK1, 2, 4 and ROCK1, increasing LIMK2 activity and leading to stabilization of the actin cytoskeleton.

WB, IHC-P

IHC-P: 1:50 - 1:100, WB: 1:500 - 1:2,000

Human, Mouse, Rat

Phospho-specific peptide corresponding to residues surrounding Thr505 of human LIMK2.

Rabbit

Polyclonal

IgG

Lot Specific

Liquid

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti LIMK2 (pThr505) antibody recognizes LIM domain kinase 2 (LIMK2), when phosphorylated at threonine 505. LIMK2 is a member of the serine/threonine protein kinase family involved in the regulation of actin cytoskeleton reorganization. LIMK2 is phosphorylated at threonine 505 by Cdc42/Rac-PAK1, 2, 4 and ROCK1, increasing LIMK2 activity and leading to stabilization of the actin cytoskeleton (Petrilli et al. 2014).

LIM domain kinase 2, LIMK-2