Anti-LTBR Antibody [5G11b] (PE) (A279443)

Anti-LTBR Antibody [5G11b] (PE)

Rat monoclonal [5G11b] antibody to LTBR (PE).

This antibody recognises mouse Tumor necrosis factor receptor superfamily member 3, also known as lymphotoxin-beta receptor, LT beta R, or Tumor necrosis factor receptor superfamily member 3. Lymphotoxin beta receptor is 385 amino acid (415 aa including 30 aa signal peptide) ~50 kDa type 1, single pass transmembrane glycoprotein and member of the tumor necrosis factor family. LT beta R is primarily expressed on stromal cells and fibroblasts and at lower levels on myeloid cell lines. recognises surface expressed LT beta R. Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b is reported to be agonistic with respect to NF Kappa B activation, MIP-2 induction and IL-6 release. Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b is routinely tested on WEH164S cells.

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl. The Fc region of monoclonal antibodies may bind to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B).

Mouse

Recombinant extracellular domain of LT beta R.

Rat

Monoclonal

5G11b

IgG2a

Protein G affinity chromatography of tissue culture supernatant.

Reconstitution dependent.

Lyophilized

Reconstitute with 1 ml of distilled water.

Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.

Lyophilized: Store at 4°C. Reconstituted: Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b recognizes murine Tumor necrosis factor receptor superfamily member 3, also known as lymphotoxin-beta receptor, LT beta R, or Tumor necrosis factor receptor superfamily member 3. Lymphotoxin beta receptor is 385 amino acid (415 aa including 30 aa signal peptide) ~50 kDa type 1, single pass transmembrane glycoprotein and member of the tumor necrosis factor family. LT beta R is primarily expressed on stromal cells and fibroblasts and at lower levels on myeloid cell lines. Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b recognizes surface expressed LT beta R. Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b is reported to be agonistic with respect to NF Kappa B activation, MIP-2 induction and IL-6 release (Hehlgans et al. 2003).Rat anti Mouse Lymphotoxin beta Receptor antibody, clone 5G11b is routinely tested on WEH164S cells.

D12S370, Lymphotoxin-beta receptor, TNF-RIII, TNFCR, TNFR-III, TNFR3, TNFRSF3, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor superfamily member 3, Tumor necrosis factor receptor type III

This product is for research use only. It is not intended for diagnostic or therapeutic use.