Anti-Macrophage Inflammatory Protein 3 alpha Antibody [O03-3H12] (Biotin) (A281353)

Anti-Macrophage Inflammatory Protein 3 alpha Antibody [O03-3H12] (Biotin)

Mouse monoclonal [O03-3H12] antibody to Macrophage Inflammatory Protein 3 alpha (Biotin).

This antibody recognises C-C motif chemokine 20, also known as LARC, MIP3A, and SCYA20. The chemokine CCL20 is expressed mostly in the lymphatic tissue, lung, and liver, and is produced by cells involved with the inflammatory and immune responses. CCL20 plays an important role in recruiting inflammatory cells to the site of infection or injury. However, CCL20 is involved with pathogenesis of chronic inflammatory disorders, specifically interstitial lung fibrosis and chronic obstructive pulmonary disease (COPD), and can contribute to tumor metastasis. Inhibition of CCL20, along with its ligand CCR6, might have valuable therapeutic potential for treatment of autoimmune and inflammatory diseases, and is therefore a target of interest for drug discovery. The biotinylated Mouse anti Human CCL20 antibody, clone O03-3H12 (MCA6203B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL20 antibody, clone J03-4D4 (MCA6202GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CCL20 (Ala27-Met96).

Mouse

Monoclonal

O03-3H12

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CCL20 antibody, clone O03-3H12, recognizes C-C motif chemokine 20, also known as LARC, MIP3A, and SCYA20. The chemokine CCL20 is expressed mostly in the lymphatic tissue, lung, and liver, and is produced by cells involved with the inflammatory and immune responses. CCL20 plays an important role in recruiting inflammatory cells to the site of infection or injury (Soto et al. 2017). However, CCL20 is involved with pathogenesis of chronic inflammatory disorders, specifically interstitial lung fibrosis and chronic obstructive pulmonary disease (COPD), and can contribute to tumor metastasis (Zhang et al. 2017). Inhibition of CCL20, along with its ligand CCR6, might have valuable therapeutic potential for treatment of autoimmune and inflammatory diseases, and is therefore a target of interest for drug discovery (Ranasinghe and Eri 2018). The biotinylated Mouse anti Human CCL20 antibody, clone O03-3H12 (MCA6203B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL20 antibody, clone J03-4D4 (MCA6202GA) as the capture antibody.

This product is for research use only. It is not intended for diagnostic or therapeutic use.