Anti-MCP4 Antibody [B16-3D8] (Biotin) (A279744)

Anti-MCP4 Antibody [B16-3D8] (Biotin)

Mouse monoclonal [B16-3D8] antibody to MCP4 (Biotin).

This antibody recognises CCL13, a member of the CC family of cytokines. CCL13, also known as MCP-4, is a 98 amino acid (aa) precursor protein which contains a 23 aa hydrophobic signal peptide that is cleaved to the mature form of the protein which is 75aa protein (8kDa). CCL13 is a chemoattractant for various cells including monocytes, T cells, immature dendritic cells and eosinophils. It has also been associated with various inflammatory diseases including asthma, arthritis, atherosclerosis and multiple sclerosis. CCL13 can bind to several chemokine receptors (CCR1, CCR2 and CCR3) to elicit chemoattractant responses. It is also known to induce degranulation of eosinophils and the secretion of pro-inflammatory cytokines. This biotinylated Mouse anti Human CCL13 antibody, clone B16-3D8 (MCA6177B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL13 antibody, clone B06-1G9 (MCA6176GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CCL13 (Phe17-Thr98).

Mouse

Monoclonal

B16-3D8

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CCL13 antibody, clone B16-3D8, recognizes CCL13, a member of the CC family of cytokines. CCL13, also known as MCP-4, is a 98 amino acid (aa) precursor protein which contains a 23 aa hydrophobic signal peptide that is cleaved to the mature form of the protein which is 75aa protein (8kDa). CCL13 is a chemoattractant for various cells including monocytes, T cells, immature dendritic cells and eosinophils (Entiquez & Garcia-Zepeda 2013). It has also been associated with various inflammatory diseases including asthma, arthritis, atherosclerosis and multiple sclerosis (Procaccini et al. 2015). CCL13 can bind to several chemokine receptors (CCR1, CCR2 and CCR3) to elicit chemoattractant responses. It is also known to induce degranulation of eosinophils and the secretion of pro-inflammatory cytokines. This biotinylated Mouse anti Human CCL13 antibody, clone B16-3D8 (MCA6177B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL13 antibody, clone B06-1G9 (MCA6176GA) as the capture antibody.

C-C motif chemokine 13, CCL13, CK-beta-10, Monocyte chemoattractant protein 4, Monocyte chemotactic protein 4, NCC-1, NCC1, SCYA13, Small-inducible cytokine A13

This product is for research use only. It is not intended for diagnostic or therapeutic use.