Anti-MEK4 / MKK4 (phospho Ser257 + Thr261) Antibody (A283653)

Anti-MEK4 / MKK4 (phospho Ser257 + Thr261) Antibody

Rabbit polyclonal antibody to MEK4 / MKK4 (phospho Ser257 + Thr261).

This antibody recognises MAPK/ERK kinase 4 (MEK 4), also known as dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4 (MAPKK 4), stress-activated protein kinase kinase 1 and JNKK, when phosphorylated at serine 257/threonine 261.MEK 4 is a dual specificity protein kinase and a member of the MAP kinase family. MEK 4 plays a key role in the MAP kinase and SAP/JNK signaling pathways.MEK 4 is activated by phosphorylation at serine 257 and threonine 261 by MAP kinase kinase kinases (MAP3Ks). Downstream targets of activated MEK4 include JNK1, JNK2 and p38 MAPK.

WB: 1:500 - 1:2,000

Human

Phospho-specific peptide corresponding to residues surrounding Ser257/threonine 261 of human MEK 4.

Rabbit

Polyclonal

IgG

Lot Specific

Liquid

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti MEK 4 (pSer257/pThr261) antibody recognizes MAPK/ERK kinase 4 (MEK 4), also known as dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4 (MAPKK 4), stress-activated protein kinase kinase 1 and JNKK, when phosphorylated at serine 257/threonine 261.MEK 4 is a dual specificity protein kinase and a member of the MAP kinase family. MEK 4 plays a key role in the MAP kinase and SAP/JNK signaling pathways.MEK 4 is activated by phosphorylation at serine 257 and threonine 261 by MAP kinase kinase kinases (MAP3Ks). Downstream targets of activated MEK4 include JNK1, JNK2 and p38 MAPK.