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Anti-Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody [DT101 + BC199 + T311 + HMB45] (A250976)

Immunohistochemistry - Anti-Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody [DT101+ BC199 + T311 + HMB45] (A250975) - Antibodies.com
$545
Product Datasheet

Mouse monoclonal [DT101 + BC199 + T311 + HMB45] antibody to Melanoma Marker (MART-1 + Tyrosinase + gp100) for IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-8 business days.

  • Specifications

Name
Anti-Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody [DT101 + BC199 + T311 + HMB45]
Description
Mouse monoclonal [DT101 + BC199 + T311 + HMB45] antibody to Melanoma Marker (MART-1 + Tyrosinase + gp100).
Specificity
This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Clone DT101 & BC199: Recombinant human MART-1 protein. Clone HMB45: Extract of pigmented melanoma metastases from lymph nodes. Clone T311: Recombinant tyrosinase protein.
Host
Mouse
Clonality
Oligoclonal
Clone ID
DT101 + BC199 + T311 + HMB45
Isotype
IgG2b, kappa + IgG1, kappa + IgG2a, kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
20-22 kDa (doublet) (MART-1): 90-100 kDa (gp100) / 70-80 kDa (Tyrosinase)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes

Please note, this product is an oligoclonal antibody; it is a cocktail of monoclonal antibodies that have been carefully selected. Oligoclonal antibodies not only have the specificity and batch-to-batch consistency of a monoclonal antibody, but they also have the advantage of the sensitivity of a polyclonal antibody due to their ability to recognize multiple epitopes on an antigen.

This oligoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody [DT101 + BC199 + T311 + HMB45] - BSA and Azide free (A254156).

Suitable Secondaries
See all Anti-Mouse IgG Secondaries →
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.

  • Scientific Validation DataValidation Data (1)

Immunohistochemistry - Anti-Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody [DT101+ BC199 + T311 + HMB45] (A250975) - Antibodies.comEnlarge Image

Immunohistochemistry - Anti-Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody [DT101 + BC199 + T311 + HMB45] (A250976)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human melanoma using Anti-Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody [DT101+ BC199 + T311 + HMB45].
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