This antibody recognises OGA (O-GlcNAcase), also known as glycoside hydrolase, BtGH84 or O-GlcNAc hydrolase.OGA catalyses the removal of O-GlcNAc post-translational modifications; a reversible enzymatic post-translational modification characterized by a ß-glycosidic bond between the hydroxyl group of serine or threonine side chains and N-acetylglucosamine (GlcNAc) Removal of O-GlcNAc from proteins like tau and the ß-amyloid protein has been linked neurological disorders.
Applications
IP, WB
Dilutions
IP: 10 µl per IP, WB: 1:500 - 1:2,000
Reactivity
Human
Immunogen
A peptide derived from within the N-terminus of human OGA.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Human OGA antibody recognizes OGA (O-GlcNAcase), also known as glycoside hydrolase, BtGH84 or O-GlcNAc hydrolase.OGA catalyses the removal of O-GlcNAc post-translational modifications; a reversible enzymatic post-translational modification characterized by a ß-glycosidic bond between the hydroxyl group of serine or threonine side chains and N-acetylglucosamine (GlcNAc) Removal of O-GlcNAc from proteins like tau and the ß-amyloid protein has been linked neurological disorders (Wells et al. 2002).
