Recombinant Anti-Mineralocorticoid Receptor Antibody [NR3C2/4900] (A315319)

Anti-Mineralocorticoid Receptor Antibody [NR3C2/4900]

Recombinant mouse monoclonal [NR3C2/4900] antibody to Mineralocorticoid Receptor.

Mineralocorticoid hormones are primarily found in epithelial tissues where they function as regulators of Na+, K+ and H+ ion transport. Aldosterone is a mineralocorticoid that has been shown to regulate electrolyte excretion and intravascular volume and is therefore involved in blood pressure regulation. Mineralocorticoid receptor (MCR or MR) is a member of the steroid/thyroid/ retinoic nuclear hormone receptor superfamily that has been shown to activate gene transcription in response to aldosterone binding. Regulation of the mineralocorticoid receptors occurs through either receptor downregulation (negative autoregulation) or hormone-mediated upregulation (positive autoregulation). MCR association with HSP 90 appears to be required for hormone binding to MCR and subsequent MCR activation.

HeLa cells. Human kidney.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 601-673) of human NR3C2 protein.

Mouse

Monoclonal

NR3C2/4900

kappa

Protein A/G chromatography.

200 µg/ml

107 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

MCR, MLR, MR, NR3C2, Nuclear receptor subfamily 3 group C member 2