This antibody recognises lysine methyltransferase 2E, otherwise known as MLL5.KMT2E is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family of proteins, a group of proteins that are homologous to the evolutionary conserved trithorax group crucial for the regulation of homeotic gene (HOX) expression and embryonic development. Aberrant levels of KMT2E have been shown to inhibit cell cycle progression. Mutations in the KMT2E gene have also been associated with neurological disorders such epilepsy and autism as well as abnormalities in gastrointestinal function (O’Donnell-Luria et al. 2019).
Applications
WB
Dilutions
WB: 1:500 - 1:2,000
Reactivity
Human, Mouse
Immunogen
A peptide derived from within human KMT2E.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Human KMT2E antibody recognizes lysine methyltransferase 2E, otherwise known as MLL5.KMT2E is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family of proteins, a group of proteins that are homologous to the evolutionary conserved trithorax group crucial for the regulation of homeotic gene (HOX) expression and embryonic development (Zhang et al. 2017). Aberrant levels of KMT2E have been shown to inhibit cell cycle progression. Mutations in the KMT2E gene have also been associated with neurological disorders such epilepsy and autism as well as abnormalities in gastrointestinal function (O’Donnell-Luria et al. 2019).
Synonyms
Inactive histone-lysine N-methyltransferase 2E, Inactive lysine N-methyltransferase 2E, KMT2E, Myeloid/lymphoid or mixed-lineage leukemia protein 5
