Anti-NFkB p105 (phospho Ser927) Antibody (A283657)

Anti-NFkB p105 (phospho Ser927) Antibody

Rabbit polyclonal antibody to NFkB p105 (phospho Ser927).

This antibody recognises human nuclear factor NF-kappa-B (NFkB) p105 subunit, also known as DNA-binding factor KBF1, EBP-1 or nuclear factor of kappa light polypeptide gene enhancer in B-cells, when phosphorylated at serine 927.NFkB p105 is a large precursor protein that is cleaved at its C-terminus (which mainly contains ankyrin repeats) by the ubiquitin/proteasome pathway into the NFkB p50 subunit. The p50 subunit, also known as NFkB1, interacts with members of the Rel protein family to form transcription factors. The NF-kappa-B pathway plays a critical role in mediating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer.NFkB p105 is phosphorylated at serine 927 and serine 932 by the I?B kinase (IKK) complex. Phosphorylation at serines 927 and 932 is required for TNF-alpha induced degradation of NFkB p105.

WB: 1:500 - 1:2,000

Human

Phospho-specific peptide corresponding to residues surrounding Ser927 of human NFkB p105.

Rabbit

Polyclonal

IgG

Lot Specific

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti NFkB p105 (pSer927) antibody recognizes human nuclear factor NF-kappa-B (NFkB) p105 subunit, also known as DNA-binding factor KBF1, EBP-1 or nuclear factor of kappa light polypeptide gene enhancer in B-cells, when phosphorylated at serine 927.NFkB p105 is a large precursor protein that is cleaved at its C-terminus (which mainly contains ankyrin repeats) by the ubiquitin/proteasome pathway into the NFkB p50 subunit. The p50 subunit, also known as NFkB1, interacts with members of the Rel protein family to form transcription factors. The NF-kappa-B pathway plays a critical role in mediating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer.NFkB p105 is phosphorylated at serine 927 and serine 932 by the I?B kinase (IKK) complex. Phosphorylation at serines 927 and 932 is required for TNF-alpha induced degradation of NFkB p105 (Lang et al. 2003).

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