This antibody recognises homeobox protein NKX-2.5.Homeobox protein NKX-2.5 is a protein encoded by the NKX2.5 gene. Homeobox-containing genes such as NKX2.5 encode for numerous transcription factors that go on to aid in the development of many structures including the heart. NKX2.5 expression is crucial for the development of atrial, ventricular, and conotruncal septation as well as the atrioventricular (AV) valve and the maintenance of AV conduction. Mutations in the NKX2.5 gene have been linked to congenital heart disease (CHD).
Applications
WB
Dilutions
WB: 1:500 - 1:1,000
Reactivity
Human
Immunogen
A peptide derived from within the N-terminus of human NKX2.5.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Human NKX2.5 antibody recognizes homeobox protein NKX-2.5.Homeobox protein NKX-2.5 is a protein encoded by the NKX2.5 gene. Homeobox-containing genes such as NKX2.5 encode for numerous transcription factors that go on to aid in the development of many structures including the heart (Bartlett et al. 2010). NKX2.5 expression is crucial for the development of atrial, ventricular, and conotruncal septation as well as the atrioventricular (AV) valve and the maintenance of AV conduction. Mutations in the NKX2.5 gene have been linked to congenital heart disease (CHD) (Wang et al. 2017).
Synonyms
Cardiac-specific homeobox, CSX, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX2-5, NKX2E
