Anti-OGR1 Antibody (A283109)

Anti-OGR1 Antibody

Rabbit polyclonal antibody to OGR1.

This antibody recognises ovarian cancer G protein-coupled receptor 1 (OGR1), a seven pass transmembrane protein initially cloned from an ovarian cancer cell line. OGR1 has a wide expression, and selectively binds both protons and bioactive lipids.OGR1 functions as a proton-sensing G protein-coupled receptor stimulating inositol phosphate production and Ca2+ mobilisation. It is also a receptor for sphingophosphorylcholine and related lysolipids, which antagonise the proton-induced actions mediated by OGR1.OGR1 is also expressed early during osteoclastogenesis and plays a role in osteoclast differentiation.

IHC-P 1: 20 µg/ml

Human, Mouse

Synthetic peptide corresponding to the N-terminal domain of human OGR1, conjugated to Keyhole Limpet Haemocyanin.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human OGR1 antibody detects ovarian cancer G protein-coupled receptor 1 (OGR1), a seven pass transmembrane protein initially cloned from an ovarian cancer cell line. OGR1 has a wide expression, and selectively binds both protons and bioactive lipids.OGR1 functions as a proton-sensing G protein-coupled receptor stimulating inositol phosphate production and Ca2+ mobilisation. It is also a receptor for sphingophosphorylcholine and related lysolipids, which antagonise the proton-induced actions mediated by OGR1.OGR1 is also expressed early during osteoclastogenesis and plays a role in osteoclast differentiation.

G-protein coupled receptor 68, GPR12A, GPR68, OGR-1, Ovarian cancer G-protein coupled receptor 1, Sphingosylphosphorylcholine receptor