Anti-p38 alpha / MAPK14 Antibody (A283418)

Anti-p38 alpha / MAPK14 Antibody

Rabbit polyclonal antibody to p38 alpha / MAPK14.

This antibody recognises mitogen-activated protein kinase p38 alpha (p38-alpha MAPK), also known as MAP kinase 14 (MAPK14) and stress activated protein kinase 2a (SAPK2a). p38 alpha is a member of the p38 MAPK serine/threonine kinase protein family, which also includes p38-beta (MAPK11), p38-gamma (MAPK12) and p38-delta (MAPK13). p38 alpha MAPK becomes activated in response to a variety of stimuli, which include inflammatory cytokines and oxidative stress. p38 alpha MAPK plays an essential role in mediating inflammation by regulating the expression of tumor necrosis factor alpha (TNF alpha) and interleukin 1 (IL-1). p38 MAPK proteins have been implicated in cancer development and p38 alpha MAPK has been proposed to act as a tumor suppressor.

WB: 1:200

Mouse, Rat, Human

A peptide corresponding to the C-terminus of mouse p38 alpha MAPK, peptide shares 100% homology with the human sequence.

Rabbit

Polyclonal

IgG

200 µg/ml

Approximately 38 kDa when run under reducing conditions

Liquid

Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti p38 alpha MAPK antibody recognizes mitogen-activated protein kinase p38 alpha (p38-alpha MAPK), also known as MAP kinase 14 (MAPK14) and stress activated protein kinase 2a (SAPK2a). p38 alpha is a member of the p38 MAPK serine/threonine kinase protein family, which also includes p38-beta (MAPK11), p38-gamma (MAPK12) and p38-delta (MAPK13) (Cargnello and Roux 2011).p38 alpha MAPK becomes activated in response to a variety of stimuli, which include inflammatory cytokines and oxidative stress (Cargnello and Roux 2011). p38 alpha MAPK plays an essential role in mediating inflammation by regulating the expression of tumor necrosis factor alpha (TNF alpha) and interleukin 1 (IL-1) (Dhillon et al. 2007). p38 MAPK proteins have been implicated in cancer development and p38 alpha MAPK has been proposed to act as a tumor suppressor (Dhillon et al. 2007).