Recombinant Anti-PAPP A Antibody [PAPPA/8804R] (A315461)

Anti-PAPP A Antibody [PAPPA/8804R]

Recombinant rabbit monoclonal [PAPPA/8804R] antibody to PAPP A.

Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

Human placenta tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment (within aa 351-523) of human PAPP-A protein. The exact sequence is proprietary.

Rabbit

Monoclonal

PAPPA/8804R

kappa

Protein A/G chromatography.

200 µg/ml

181 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

IGF-dependent IGFBP-4 protease, IGFBP-4ase, Insulin-like growth factor-dependent IGF-binding protein 4 protease, PAPP-A, PAPPA, Pappalysin-1, Pregnancy-associated plasma protein A