Recombinant Anti-PRAME Antibody [PRAME/6928R] (A315529)

Anti-PRAME Antibody [PRAME/6928R]

Recombinant rabbit monoclonal [PRAME/6928R] antibody to PRAME.

Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.

Human testis or melanoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 100-509) of human PRAME protein. The exact sequence is proprietary.

Rabbit

Monoclonal

PRAME/6928R

kappa

Protein A/G chromatography.

200 µg/ml

58 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

MAPE, Melanoma antigen preferentially expressed in tumors, OIP-4, OIP4, Opa-interacting protein 4, Preferentially expressed antigen of melanoma