Anti-Properdin / PFC Antibody [062-260 (10-24)] (A278911)

Anti-Properdin / PFC Antibody [062-260 (10-24)]

Mouse monoclonal [062-260 (10-24)] antibody to Properdin / PFC.

This antibody recognises human complement factor P, a 53 kDa glycosylated protein present in serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections. Mouse anti Human complement factor P antibody, clone 10-24 does not inhibit function of complement factor P.

ELISA, IHC-Fr, WB

Human

Purified human factor P from human serum.

Mouse

Monoclonal

062-260 (10-24)

IgG1

1 mg/ml

Liquid

Supplied in Borate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human complement factor P antibody, clone 062-260 (10-24) recognises human complement factor P, a 53 kDa glycosylated protein present in serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections.Mouse anti Human complement factor P antibody, clone 10-24 does not inhibit function of complement factor P.