Anti-Properdin / PFC Antibody [062-27.8.1 (10-18)] (A278912)

Anti-Properdin / PFC Antibody [062-27.8.1 (10-18)]

Mouse monoclonal [062-27.8.1 (10-18)] antibody to Properdin / PFC.

This antibody recognises human factor P, a 53 kDa glycosylated protein present in blood serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections. Mouse anti Human Factor P antibody, clone 10-18 is reported to inhibit the function of factor P. Removal of sodium azide is recommended prior to use in functional assays.

Flow Cytometry, ELISA, IHC-Fr, WB, Functional Assays

Flow Cytometry: 1:1,000, IHC-Fr: 1:1,000

Human

Native purified factor P from human serum.

Mouse

Monoclonal

062-27.8.1 (10-18)

IgG1

Protein A affinity chromatography of ascites.

1 mg/ml

Liquid

Supplied in Borate Buffered Saline with 0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human Factor P antibody, clone 062-27.8.1 (10-18) recognizes human factor P, a 53 kDa glycosylated protein present in blood serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections.Mouse anti Human Factor P antibody, clone 10-18 is reported to inhibit the function of factor P. Removal of sodium azide is recommended prior to use in functional assays.