Anti-RAGE Antibody [A09-5H8] (Biotin) (A279585)

Anti-RAGE Antibody [A09-5H8] (Biotin)

Mouse monoclonal [A09-5H8] antibody to RAGE (Biotin).

This antibody recognises Receptor for Advanced Glycosylation End products (RAGE), also known as advanced glycosylation end product-specific receptor. RAGE is a multi-ligand receptor belonging to the immunoglobulin receptor subfamily. It has many endogenous and exogenous ligands and upon binding of a ligand, RAGE can stimulate various signaling pathways including NF-?B, AP-1, CREB and STAT3. Triggering these pathways can then induce cytokine/chemokine transcription. This can be used to regulate the innate immune response, inflammation resolution, tissue homeostasis and tissue repair following injury. The biotinylated Mouse anti Human RAGE antibody, clone A09-5H8 (MCA6277B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human RAGE antibody, clone B02-4G7 (MCA6276GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length RAGE (Ala23-Pro404).

Mouse

Monoclonal

A09-5H8

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human RAGE antibody, clone A09-5H8, recognizes Receptor for Advanced Glycosylation End products (RAGE), also known as advanced glycosylation end product-specific receptor. RAGE is a multi-ligand receptor belonging to the immunoglobulin receptor subfamily. It has many endogenous and exogenous ligands and upon binding of a ligand, RAGE can stimulate various signaling pathways including NF-?B, AP-1, CREB and STAT3. Triggering these pathways can then induce cytokine/chemokine transcription (Sorci et al. 2013). This can be used to regulate the innate immune response, inflammation resolution, tissue homeostasis and tissue repair following injury (Plotkin et al. 2019).The biotinylated Mouse anti Human RAGE antibody, clone A09-5H8 (MCA6277B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human RAGE antibody, clone B02-4G7 (MCA6276GA) as the capture antibody.

Advanced glycosylation end product-specific receptor, AGER, Receptor for advanced glycosylation end products

This product is for research use only. It is not intended for diagnostic or therapeutic use.