Anti-Renalase Antibody [RNLS/1940] (A249707)

Anti-Renalase Antibody [RNLS/1940]

Mouse monoclonal [RNLS/1940] antibody to Renalase.

Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.

Human

Recombinant fragment, around amino acids 34-235, of human RNLS protein. The exact sequence is proprietary.

Mouse

Monoclonal

RNLS/1940

IgG2b

kappa

Protein A/G chromatography.

200 µg/ml

38 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Renalase Antibody [RNLS/1940] - BSA and Azide free (A252887).

C10orf59, MAO-C, Monoamine oxidase-C, RNLS