General Notes
Mouse anti Respiratory syncitial virus antibody, clone 0651 detects the fusion protein of human respiratory syncytial virus (RSV), groups A and B. RSV is a negative-sense, single-stranded RNA virus and is a member of the Paramyxoviridae family. RSV causes respiratory tract infections in patients of all ages, but particularly affects infants and the immunosuppressed. RSV encodes three envelope glycoproteins, a small hydrophobic (SH) protein of unknown function, a glycoprotein (G) known as the attachment protein, and a fusion (F) protein. The F protein directs fusion of viral and cellular membranes, resulting in viral penetration, and can lead to the formation of syncytia. The F protein is thought to be the principal antigen responsible for inducing an immune response.