Recombinant Anti-ROS1 Antibody [ROS1/7999R] - BSA and Azide free (A316939)

Anti-ROS1 Antibody [ROS1/7999R] - BSA and Azide free

Recombinant rabbit monoclonal [ROS1/7999R] antibody to ROS1.

ROS1, an orphan receptor tyrosine kinase of the insulin receptor family, was initially identified as a homolog of v-ros from the UR2 sarcoma virus. ROS1 consists of a large extracellular domain that is composed of six fibronectin repeats, a transmembrane domain, and an intracellular kinase domain. While the function of ROS1 is undefined, it has been shown to play an important role in differentiation of epididymal epithelium. The first oncogenic fusion of ROS1, FIG-ROS1, was initially identified by research studies in glioblastoma. Investigators have found additional oncogenic ROS1 fusion proteins in NSCLC (at a frequency of ~1.6%), where the ROS1 kinase domain is fused to the amino-terminal region of a number of different proteins, including CD74 and SLC34A2.

Human brain, lung carcinoma or primary glioblastoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment corresponding to cytoplasmic domain of human ROS1 protein.

Rabbit

Monoclonal

ROS1/7999R

kappa

Protein A/G chromatography.

1 mg/ml

264 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

c-Ros receptor tyrosine kinase, MCF3, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Proto-oncogene tyrosine-protein kinase ROS, Receptor tyrosine kinase c-ros oncogene 1, ROS