Anti-RRAGC Antibody [AB02/2G5] (A320290)

Anti-RRAGC Antibody [AB02/2G5]

Mouse monoclonal [AB02/2G5] antibody to RRAGC.

This antibody recognises ras-related GTP-binding protein C subunit beta-1, otherwise known as GTPase-interacting protein 2.RRAGC is a monomeric guanine nucleotide binding protein that functions as a heterodimer with rag A or rag B. The binding of this heterodimer to mTORC1 leads to mTORC1 being recruited to the surface of lysosomes; thereby enabling mTORC1 to associate with rheb and become activated (Sancak et al. 2010; Yang et al. 2017). Upon amino acid depletion, Rag heterodimers release mTORC1 into the cytosol; suggesting that Rags control mTORC1 signaling in response to amino acid levels (Fingar, 2021). Mouse anti Human RRAGC antibody detects a band of 49 kDa.

WB: 1:1,000

Human, Mouse, Rat

E. coli derived recombinant protein corresponding to amino acids 1-399 of human RRAGC.

MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI

Mouse

Monoclonal

AB02/2G5

IgG1

Protein G affinity chromatography of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human RRAGC antibody recognizes ras-related GTP-binding protein C subunit beta-1, otherwise known as GTPase-interacting protein 2.RRAGC is a monomeric guanine nucleotide binding protein that functions as a heterodimer with rag A or rag B. The binding of this heterodimer to mTORC1 leads to mTORC1 being recruited to the surface of lysosomes; thereby enabling mTORC1 to associate with rheb and become activated (Sancak et al. 2010; Yang et al. 2017). Upon amino acid depletion, Rag heterodimers release mTORC1 into the cytosol; suggesting that Rags control mTORC1 signaling in response to amino acid levels (Fingar, 2021).Mouse anti Human RRAGC antibody detects a band of 49 kDa.

GTPase-interacting protein 2, Rag C, RagC, Ras-related GTP-binding protein C, TIB929