Anti-Serum Amyloid P / SAP Antibody [AB12-5A1] (Biotin) (A279625)

Anti-Serum Amyloid P / SAP Antibody [AB12-5A1] (Biotin)

Mouse monoclonal [AB12-5A1] antibody to Serum Amyloid P / SAP (Biotin).

This antibody recognises Serum Amyloid P-component (SAP) also known as 9.5S alpha-1-glycoprotein, a member of the pentraxin family of proteins. It is synthesized by hepatocytes and secreted into the blood. In humans the levels of SAP range between 20-50 µg/ml. SAP is able to bind to a variety of molecules including apoptotic debris, bacterial polysaccharides, amyloid deposits and bacterial toxins. Phagocytic cells such as monocytes and macrophages then bind the SAP and engulf the material bound to SAP as part of debris clearance. The biotinylated Mouse anti Human SAP antibody, clone AB12-5A1 (MCA6269B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human SAP antibody, clone AB18-4E2 (MCA6268GA) as the capture antibody.

ELISA: 1 µg/ml

Human

Native SAP purified from human serum.

Mouse

Monoclonal

AB12-5A1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human SAP antibody, clone AB12-5A1, recognizes Serum Amyloid P-component (SAP) also known as 9.5S alpha-1-glycoprotein, a member of the pentraxin family of proteins. It is synthesized by hepatocytes and secreted into the blood. In humans the levels of SAP range between 20-50 µg/ml (Pilling & Gomer 2018). SAP is able to bind to a variety of molecules including apoptotic debris, bacterial polysaccharides, amyloid deposits and bacterial toxins. Phagocytic cells such as monocytes and macrophages then bind the SAP and engulf the material bound to SAP as part of debris clearance (Pilling & Gomer 2018).The biotinylated Mouse anti Human SAP antibody, clone AB12-5A1 (MCA6269B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human SAP antibody, clone AB18-4E2 (MCA6268GA) as the capture antibody.

This product is for research use only. It is not intended for diagnostic or therapeutic use.