Anti-Sialoadhesin / CD169 Antibody [MOMA-1] (A281244)

Anti-Sialoadhesin / CD169 Antibody [MOMA-1]

Rat monoclonal [MOMA-1] antibody to Sialoadhesin / CD169.

This antibody recognises mouse CD169, also known as sialoadhesin or Siglec-1. CD169 is a lectin-like receptor expressed by certain populations of macrophages including marginal zone metallophils of the spleen, subcapsular macrophages of lymph nodes and stromal macrophages in bone marrow. CD169 is a ~185 kDa sialic acid binding receptor containing 17 immunoglobulin-like domains. Expression of CD169 can be induced on macrophages in culture by a serum factor and further modulated by cytokine exposure. Rat anti mouse CD169, clone MOMA-1 has been used for the in vivo depletion of specific macrophage populations.

IF, IHC-Fr

Mouse

This antibody does not cross react with Human or Rat

Stromal (reticular) elements from mouse lymph nodes.

Rat

Monoclonal

MOMA-1

IgG2a

Protein G affinity chromatography of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rat anti Mouse CD169, clone MOMA-1 recognizes murine CD169, also known as sialoadhesin or Siglec-1. CD169 is a lectin-like receptor expressed by certain populations of macrophages including marginal zone metallophils of the spleen, subcapsular macrophages of lymph nodes and stromal macrophages in bone marrow (Morris et al. 1991). CD169 is a ~185 kDa sialic acid binding receptor containing 17 immunoglobulin-like domains (Crocker et al. 1992). Expression of CD169 can be induced on macrophages in culture by a serum factor and further modulated by cytokine exposure (McWilliam et al. 1992). Rat anti mouse CD169, clone MOMA-1 has been used for the in vivo depletion of specific macrophage populations (Kraal et al. 1988).