Recombinant Anti-TMEM16A Antibody [rDG1/447] - BSA and Azide free (A317120)

Anti-TMEM16A Antibody [rDG1/447] - BSA and Azide free

Recombinant mouse monoclonal [rDG1/447] antibody to TMEM16A.

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.

Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.

IHC: 1-2 µg/ml

Human

Recombinant full-length human DOG-1 protein.

Mouse

Monoclonal

rDG1/447

kappa

Protein A/G chromatography.

1 mg/ml

~114 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

ANO1, Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, DOG1, Oral cancer overexpressed protein 2, ORAOV2, TAOS2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2