Anti-TNFS15 Antibody [VEGI/1283] (A250818)

Anti-TNFS15 Antibody [VEGI/1283]

Mouse monoclonal [VEGI/1283] antibody to TNFS15.

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment of human VEGI protein.

Mouse

Monoclonal

VEGI/1283

IgG1

Protein A/G chromatography.

200 µg/ml

22 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TNFS15 Antibody [VEGI/1283] - BSA and Azide free (A253998).