Anti-TNFSF9 Antibody [CD137L/1547] (A250439)

Anti-TNFSF9 Antibody [CD137L/1547]

Mouse monoclonal [CD137L/1547] antibody to TNFSF9.

TNFSF9 / 4-1BBL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9 / 4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9 / 4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. It has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine is required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Flow Cytometry, IHC-P

Flow Cytometry: 1-2 µg/million cells, IHC-P: 1-2 µg/ml

Human

Recombinant full-length human CD137L protein.

Mouse

Monoclonal

CD137L/1547

IgG2a

kappa

Protein A/G chromatography.

200 µg/ml

27 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TNFSF9 Antibody [CD137L/1547] - BSA and Azide free (A253619).

4-1BB ligand, Tumor necrosis factor ligand superfamily member 9