Mouse monoclonal [2C11] antibody to TSH Receptor / TSH-R.
Specificity
This antibody recognises the human thyroid stimulating hormone receptor (TSHR) otherwise known as the thyrotropin receptor. TSHR is an important molecule in controlling the growth and function of the normal thyroid.recognises the mutant TSH receptor known as I167N as well as the wild type molecule
Applications
WB, IP, Flow Cytometry, ELISA
Dilutions
IP: 5 µg/ml - 10 µg/ml, WB: 5 µg/ml - 10 µg/ml
Reactivity
Human
Immunogen
Recombinant human TSH receptor.
Host
Mouse
Clonality
Monoclonal
Clone ID
2C11
Isotype
IgG1
Conjugate
Unconjugated
Purification
Protein A affinity chromatography of tissue culture supernatant.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti Human thyroid stimulating hormone receptor antibody, clone 2C11 recognizes the human thyroid stimulating hormone receptor (TSHR) otherwise known as the thyrotropin receptor. TSHR is an important molecule in controlling the growth and function of the normal thyroid.Mouse anti Human thyroid stimulating receptor antibody recognises both native and denatured TSH receptor (binding to an epitope at the carboxy terminus between amino acids 354 and 359). It does inhibit binding of TSH. No cross reactivity has been observed with related LH and FSH receptors.Mouse anti Human thyroid stimulating hormone receptor antibody, clone 2C11 recognizes the mutant TSH receptor known as I167N as well as the wild type molecule (Costagliola et al. 1998)
