Anti-TWEAKR / FN14 Antibody [ITEM-4] (PE) (A280758)

Anti-TWEAKR / FN14 Antibody [ITEM-4] (PE)

Mouse monoclonal [ITEM-4] antibody to TWEAKR / FN14 (PE).

This antibody recognises human tumor necrosis factor receptor superfamily member 12A, also known as CD266, Fibroblast growth factor-inducible immediate-early response protein 14 or Tweak-receptor. CD266 is a 102 amino acid ~14 kDa type I transmembrane glycoprotein and member of the tumour necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of tissues, including the heart, lung and kidney, and at elevated levels by human brain and liver tumors.The interaction between CD266 and its ligand CD255 (TWEAK), induces the proliferation and migration of endothelial cells and also angiogenesis, and CD255-induced apoptosis of some tumor cell lines is mediated by CD266. Mouse anti Human CD266 antibody, clone ITEM-4 is cross-reactive with mouse CD266, and also with Rat-1 fibroblastoid cells in flow cytometry.

Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Human, Mouse, Rat

Human CD266 transfected P815 cells.

Mouse

Monoclonal

ITEM-4

IgG2b

Protein G affinity chromatography of tissue culture supernatant.

Reconstitution dependent.

Lyophilized

Reconstitute with 1 ml of distilled water

Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.

Lyophilized: Store at 4°C. Reconstituted: Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD266 antibody, clone ITEM-4 recognizes human tumor necrosis factor receptor superfamily member 12A, also known as CD266, Fibroblast growth factor-inducible immediate-early response protein 14 or Tweak-receptor. CD266 is a 102 amino acid ~14 kDa type I transmembrane glycoprotein and member of the tumour necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of tissues, including the heart, lung and kidney, and at elevated levels by human brain and liver tumors.The interaction between CD266 and its ligand CD255 (TWEAK), induces the proliferation and migration of endothelial cells and also angiogenesis, and CD255-induced apoptosis of some tumor cell lines is mediated by CD266 (Nakayama et al. 2003).Mouse anti Human CD266 antibody, clone ITEM-4 is cross-reactive with mouse CD266, and also with Rat-1 fibroblastoid cells in flow cytometry.

This product is for research use only. It is not intended for diagnostic or therapeutic use.