This antibody recognises undifferentiated embryonic cell transcription factor 1.UTF1 is a protein expressed in the nuclei of pluripotent cells such as embryonic stem cells and embryonic carcinoma cells where it regulates chromatin state and mRNA levels by promoting degradation of mRNA. Expression of UTF1 quickly reduces upon differentiation. UTF1 is overexpressed in cervical cancer cells.
Applications
WB
Dilutions
WB: 1:500 - 1:1,000
Reactivity
Human, Mouse
Immunogen
A peptide derived from within the N-terminus of human UTF1.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Human UTF1 antibody recognizes undifferentiated embryonic cell transcription factor 1.UTF1is aprotein expressed in the nuclei of pluripotent cells such asembryonic stem cellsand embryonic carcinoma cells where it regulates chromatinstate and mRNAlevels by promoting degradation ofmRNA (Jia et al. 2012). Expression of UTF1 quickly reduces upondifferentiation. UTF1 is overexpressed incervical cancercells (Guenin et al. 2012).
