Anti-YKL-40 / CHI3L1 Antibody [G03-2H1] (Biotin) (A280491)

Anti-YKL-40 / CHI3L1 Antibody [G03-2H1] (Biotin)

Mouse monoclonal [G03-2H1] antibody to YKL-40 / CHI3L1 (Biotin).

This antibody recognises YKL-40, also known as chitinase-3-like protein 1, 39kDA synovial protein and cartilage glycoprotein 39. YKL-40 is a glycoprotein and a member of the mammalian chitinase-like proteins. It is expressed by a variety of cells including macrophages, neutrophils, chondrocytes, fibroblasts, vascular smooth muscle cells, endothelial cells and epithelials cells. YKL-40 induces the maturation of monocytes to macrophages and is secreted by macrophages during late stages of differentiation and by activated macrophages. It has also been shown to be an adhesion and migration factor for vascular cells. The biotinylated Mouse anti Human YKL-40 antibody, clone G03-2H1 (MCA6291B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human YKL-40 antibody, clone G06-10H11 (MCA6290GA) as the capture antibody.

ELISA: 1 µg/ml

Human

NS0 derived recombinant full length human YKL-40 (Tyr22-Thr383).

Mouse

Monoclonal

G03-2H1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human YKL-40 antibody, clone G03-2H1, recognizes YKL-40, also known as chitinase-3-like protein 1, 39kDA synovial protein and cartilage glycoprotein 39. YKL-40 is a glycoprotein and a member of the mammalian chitinase-like proteins (Johansen et al. 2006). It is expressed by a variety of cells including macrophages, neutrophils, chondrocytes, fibroblasts, vascular smooth muscle cells, endothelial cells and epithelials cells (Lee et al. 2011). YKL-40 induces the maturation of monocytes to macrophages and is secreted by macrophages during late stages of differentiation and by activated macrophages. It has also been shown to be an adhesion and migration factor for vascular cells (Rathcke & Vestergaard 2009). The biotinylated Mouse anti Human YKL-40 antibody, clone G03-2H1 (MCA6291B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human YKL-40 antibody, clone G06-10H11 (MCA6290GA) as the capture antibody.

This product is for research use only. It is not intended for diagnostic or therapeutic use.