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Anti-ZFYVE28 Antibody [LST2/2426] (A249777)

Mouse monoclonal [LST2/2426] antibody to ZFYVE28 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 5-8 business days.
Name
Anti-ZFYVE28 Antibody [LST2/2426]
Description
Mouse monoclonal [LST2/2426] antibody to ZFYVE28.
Specificity
ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human ZFYVE28 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
LST2/2426
Isotype
IgG2a
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
96 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-ZFYVE28 Antibody [LST2/2426] - BSA and Azide free (A252957).
Synonyms
hLst2, KIAA1643, Lateral signaling target protein 2 homolog, LST2, Zinc finger FYVE domain-containing protein 28
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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Proteins predicted to interact with ZFYVE28

Predicted protein interactions based upon String database. Revelancy score correlates with probability of interaction.
69% Relevancy Score
57.1% Relevancy Score
49.2% Relevancy Score
47.7% Relevancy Score
44.2% Relevancy Score
39.1% Relevancy Score
37% Relevancy Score
33.6% Relevancy Score
32.5% Relevancy Score