Anti-CCR7 Antibody [4B12] (A279346)

Anti-CCR7 Antibody [4B12]

Rat monoclonal [4B12] antibody to CCR7.

This antibody recognises mouse C-C chemokine receptor type 7, also known as CD197, Epstein-Barr virus-induced G-protein coupled receptor 1, CCR7 or MIP-3 beta receptor. CD197 is a 354 amino acid ~43 kDa member of the G-protein coupled receptor family. In mice, CD197 is expressed on most naïve T cells, a subset of memory T cells, B cells, mature dendritic cells, NK cells, a subset of thymocytes and CD34+ macrophage progenitor cells.CD197 is a functional receptor for chemokines CCL21 and CCL19. The receptor plays an important role in regulating the trafficking and homing of lymphocytes and dendritic cells to secondary lymphoid organs.Rat anti Mouse CD197 antibody, clone 4B12 does not block the binding of the ligand to CD197.

IP, Flow Cytometry

Flow Cytometry: 1:25 - 1:100, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Mouse

CCR7 rat basophilic leukaemia (RBL)-2H3 transfectants.

Rat

Monoclonal

4B12

IgG2a

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rat anti Mouse CD197 antibody, clone 4B12 recognizes murine C-C chemokine receptor type 7, also known as CD197, Epstein-Barr virus-induced G-protein coupled receptor 1, CCR7 or MIP-3 beta receptor. CD197 is a 354 amino acid ~43 kDa member of the G-protein coupled receptor family. In mice, CD197 is expressed on most naïve T cells, a subset of memory T cells, B cells, mature dendritic cells, NK cells, a subset of thymocytes and CD34+ macrophage progenitor cells.CD197 is a functional receptor for chemokines CCL21 and CCL19. The receptor plays an important role in regulating the trafficking and homing of lymphocytes and dendritic cells to secondary lymphoid organs.Rat anti Mouse CD197 antibody, clone 4B12 does not block the binding of the ligand to CD197.

BLR 2, BLR2, C C chemokine receptor type 7, C C CKR 7, C-C chemokine receptor type 7, C-C CKR-7, CC chemokine receptor 7, CC chemokine receptor type 7, CC CKR 7, CC-CKR-7, CCCKR7, CCR 7, CCR-7, CCR7_HUMAN, CD 197, CD197, CD197 antigen, CDw197, Chemokine (C C motif) receptor 7, Chemokine (C C) receptor 7, Chemokine C C motif receptor 7, Chemokine C C receptor 7, Chemokine receptor 7, Chemokine receptor 7-like protein, CMKBR7, EBI 1, EBI1, Ebi1h, EBV Induced G Protein Coupled Receptor 1, EBV-induced G-protein coupled receptor 1, Epstein Barr virus induced G protein coupled receptor, Epstein Barr virus induced gene 1, Epstein-Barr virus-induced G-protein coupled receptor 1, EVI 1, EVI1, Lymphocyte Specific G Protein Coupled Peptide Receptor, MGC108519, MIP 3 beta receptor, MIP-3 beta receptor, MIP3 Beta Receptor