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Anti-CD107b Antibody

 
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Total Citations (85)
Mouse monoclonal (H4B4) antibody to CD107b from Antibodies.com (A86605).

   Please Note: This is exactly the same antibody that is marketed as:


 
   •  Abcam | ab25631
   •  Novus Biologicals | NBP2-22217
Name: Anti-CD107b Antibody
Description: Mouse monoclonal (H4B4) antibody to CD107b.
Specificity: The mouse monoclonal antibody H4B4 recognizes CD107b / LAMP-2, an extensively glycosylated 100-120 kDa widely expressed lysosome-associated protein.
Applications: FC, WB, IHC-P, IHC-Fr, ICC
Reactivity: Human
Immunogen: Human PBMC.
Host: Mouse
Clonality: Monoclonal
Clone: H4B4
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 µm filter sterilised).
Storage: Store at 2-8°C.
Introduction: CD107b (lysosome-associated membrane protein-2, LAMP-2), together with CD107a / LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa.
Synonyms: CD107 antigen-like family member B Antibody
LAMP 2 Antibody
Lamp 2a Antibody
LAMP 2C Antibody
LAMP-2 Antibody
LAMP2 Antibody
LAMP2A Antibody
LAMP2_HUMAN Antibody
LAMPB Antibody
LGP110 Antibody
Lysosomal associated membrane protein 2 Antibody
Lysosome associated membrane protein 2 Antibody
Lysosome-associated membrane glycoprotein 2 Antibody
Lysosome-associated membrane protein 2 Antibody
MAC3 Antibody

   Please Note: These publications cite this antibody under different brand names & catalogue numbers.


Cites NBP2-22217

Warren RA, Green FA, Stenberg PE, Enns CA. Distinct saturable pathways for the endocytosis of different tyrosine motifs. J Biol Chem. 1998 Jul 3

Cites NBP2-22217

Garcia-del Portillo F, Stein MA, Finlay BB. Release of lipopolysaccharide from intracellular compartments containing Salmonella typhimurium to vesicles of the host epithelial cell. Infect Immun. 1997 Jan

Cites ab25631

Horn AV  et al. A conserved role for the ESCRT membrane budding complex in LINE retrotransposition. PLoS Genet 13:e1006837 (2017).

Cites ab25631

Bhattacharya S  et al. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci 58:2366-2387 (2017).

Cites ab25631

Lu S  et al. Lysosomal adaptation: How cells respond to lysosomotropic compounds. PLoS One 12:e0173771 (2017).

Cites ab25631

Jung J  et al. Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife 6:N/A (2017).

Cites NBP2-22217

Lee WH, Higuchi H, Ikeda S et al. Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. Elife. Nov 15 2016

Cites ab25631

White SH  et al. Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study. J Transl Med 14:284 (2016).

Cites ab25631

Marycz K  et al. Equine metabolic syndrome impairs adipose stem cells osteogenic differentiation by predominance of autophagy over selective mitophagy. J Cell Mol Med : (2016).

Cites ab25631

Dyachok J  et al. Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism. J Biol Chem 291:22414-22426 (2016).

Cites ab25631

Soo KY  et al. ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1. Cell Death Discov 1:15030 (2015).

Cites ab25631

Liao C  et al. Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. Oncotarget 7:47387-47402 (2016).

Cites ab25631

Hoxhaj G  et al. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids. Elife 5:N/A (2016).

Cites ab25631

Ma J  et al. Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Res 26:713-27 (2016).

Cites ab25631

Jennewein L  et al. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget 7:20016-32 (2016).

Cites ab25631

Tillotson BJ  et al. Engineering an Anti-Transferrin Receptor ScFv for pH-Sensitive Binding Leads to Increased Intracellular Accumulation. PLoS One 10:e0145820 (2015).

Cites ab25631

Ye Z  et al. PRL-3 activates mTORC1 in Cancer Progression. Sci Rep 5:17046 (2015).

Cites ab25631

Zhao GX  et al. The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. Oncotarget 6:38952-66 (2015).

Cites ab25631

Mancias JD  et al. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Elife 4:N/A (2015).

Cites ab25631

Fan SJ  et al. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. Oncogene 35:3004-15 (2016).

Cites ab25631

Giuliano S  et al. Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux. Autophagy 11:1891-904 (2015).

Cites ab25631

Jubrail J  et al. Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages. Cell Microbiol 18:80-96 (2016).

Cites ab25631

Huna A  et al. Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle 14:2969-84 (2015).

Cites ab25631

Jung J  et al. Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9. Mol Cell Biol 35:2479-94 (2015).

Cites ab25631

Cheng HW  et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis 6:e1753 (2015).

Cites ab25631

Akizu N  et al. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet 47:528-34 (2015).

Cites ab25631

Muñoz-Galván S  et al. MAP17 (PDZKIP1) Expression Determines Sensitivity to the Proteasomal Inhibitor Bortezomib by Preventing Cytoprotective Autophagy and NF?B Activation in Breast Cancer. Mol Cancer Ther 14:1454-65 (2015).

Cites ab25631

Ghosh A  et al. Activation of peroxisome proliferator-activated receptor a induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders. J Biol Chem 290:10309-24 (2015).

Cites ab25631

Jansson PJ  et al. Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp). J Biol Chem 290:9588-603 (2015).

Cites ab25631

Brahimi-Horn MC  et al. Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Mol Cell Biol 35:1491-505 (2015).

Cites NBP2-22217

Nighot PK, Hu CA, Ma TY. Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation. J Biol Chem 2015 Mar 13

Cites ab25631

Shostak K  et al. NF-?B-induced KIAA1199 promotes survival through EGFR signalling. Nat Commun 5:5232 (2014).

Cites ab25631

Gutierrez E  et al. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem 289:33568-89 (2014).

Cites NBP2-22217

Choi Yp, Head Mw, Ironside Jw, Priola Sa. Uptake and Degradation of Protease-Sensitive and -Resistant Forms of Abnormal Human Prion Protein Aggregates by Human Astrocytes. Am J Pathol 2014 Sep 29

Cites ab25631

Apelland T  et al. Familial globotriaosylceramide-associated cardiomyopathy mimicking Fabry disease. Heart N/A:N/A (2014).

Cites ab25631

Zaganjor E  et al. Ras transformation uncouples the kinesin-coordinated cellular nutrient response. Proc Natl Acad Sci U S A 111:10568-73 (2014).

Cites ab25631

Cottam EM  et al. Coronavirus NSP6 restricts autophagosome expansion. Autophagy 10:1426-41 (2014).

Cites ab25631

Aflaki E  et al. Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs. Sci Transl Med 6:240ra73 (2014).

Cites ab25631

Mancias JD  et al. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 509:105-9 (2014).

Cites ab25631

Leitch CC  et al. Basal body proteins regulate Notch signaling through endosomal trafficking. J Cell Sci 127:2407-19 (2014).

Cites ab25631

Wolff NA  et al. Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). FASEB J 28:2134-45 (2014).

Cites ab25631

Huenchuguala S  et al. Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction. Autophagy 10:618-30 (2014).

Cites ab25631

Matsuda-Lennikov M  et al. Lysosomal interaction of Akt with Phafin2: a critical step in the induction of autophagy. PLoS One 9:e79795 (2014).

Cites ab25631

Liu B  et al. Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. Autophagy 10:416-30 (2014).

Cites ab25631

Liu WJ  et al. Autophagy activation reduces renal tubular injury induced by urinary proteins. Autophagy 10:243-56 (2014).

Cites ab25631

Oshiro N  et al. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J Biol Chem 289:2658-74 (2014).

Cites ab25631

Qin Y  et al. The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. Hum Mol Genet 23:2428-39 (2014).

Cites ab25631

Tattoli I  et al. Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures. EMBO J 32:3066-78 (2013).

Cites ab25631

Shin JY  et al. Mesenchymal stem cells enhance autophagy and increase ß-amyloid clearance in Alzheimer disease models. Autophagy 10:32-44 (2014).

Cites ab25631

Cesen MH  et al. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis 4:e818 (2013).

Cites ab25631

Yamagishi T  et al. P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration. J Biol Chem 288:31761-71 (2013).

Cites ab25631

Nikonov A  et al. RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication. PLoS Pathog 9:e1003610 (2013).

Cites ab25631

Iordanova B  et al. Engineered mitochondrial ferritin as a magnetic resonance imaging reporter in mouse olfactory epithelium. PLoS One 8:e72720 (2013).

Cites ab25631

Zhang L  et al. Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress. Cancer Lett 339:49-59 (2013).

Cites ab25631

Varjak M  et al. Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus. J Virol 87:10295-312 (2013).

Cites ab25631

Oner SS  et al. Translocation of activator of G-protein signaling 3 to the Golgi apparatus in response to receptor activation and its effect on the trans-Golgi network. J Biol Chem 288:24091-103 (2013).

Cites ab25631

Jeric B  et al. N-terminally truncated forms of human cathepsin F accumulate in aggresome-like inclusions. Biochim Biophys Acta 1833:2254-66 (2013).

Cites ab25631

Jiang L  et al. Cellular uptake mechanism and intracellular fate of hydrophobically modified pullulan nanoparticles. Int J Nanomedicine 8:1825-34 (2013).

Cites ab25631

Stalder L  et al. The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing. EMBO J 32:1115-27 (2013).

Cites ab25631

Tattoli I  et al. The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuole. Biol Open 1:1215-25 (2012).

Cites ab25631

Lin LL  et al. Revealing the molecular mechanism of gastric cancer marker annexin A4 in cancer cell proliferation using exon arrays. PLoS One 7:e44615 (2012).

Cites ab25631

Lin LL  et al. Helicobacter pylori disrupts host cell membranes, initiating a repair response and cell proliferation. Int J Mol Sci 13:10176-92 (2012).

Cites ab25631

Dibble CC  et al. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell 47:535-46 (2012).

Cites ab25631

Koshkaryev A  et al. Bleomycin in octaarginine-modified fusogenic liposomes results in improved tumor growth inhibition. Cancer Lett 334:293-301 (2013).

Cites ab25631

Tattoli I  et al. Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe 11:563-75 (2012).

Cites ab25631

Ogmundsdóttir MH  et al. Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes. PLoS One 7:e36616 (2012).

Cites ab25631

Chaparro-Riggers J  et al. Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9. J Biol Chem 287:11090-7 (2012).

Cites ab25631

Chimote AA  et al. Disruption of kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes. J Biol Chem 287:2055-67 (2012).

Cites ab25631

Yamada M  et al. Hepatitis B virus envelope L protein-derived bio-nanocapsules: mechanisms of cellular attachment and entry into human hepatic cells. J Control Release 160:322-9 (2012).

Cites ab25631

Yang S  et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev 25:717-29 (2011).

Cites ab25631

Ho H  et al. WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition. J Biol Chem : (2011).

Cites ab25631

Bianco SD  et al. KISS1R Intracellular Trafficking and Degradation: Effect of the Arg386Pro Disease-Associated Mutation. Endocrinology 152:1616-26 (2011).

Cites ab25631

Couve E & Schmachtenberg O Autophagic activity and aging in human odontoblasts. J Dent Res 90:523-8 (2011).

Cites ab25631

Humphries WH  et al. Intracellular degradation of low-density lipoprotein probed with two-color fluorescence microscopy. Integr Biol (Camb) 2:536-44 (2010).

Cites ab25631

Mukhopadhyay S  et al. Manganese-induced trafficking and turnover of the cis-Golgi glycoprotein GPP130. Mol Biol Cell 21:1282-92 (2010).

Cites ab25631

Vural A  et al. Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable. Mol Cell Biol 30:1528-40 (2010).

Cites ab25631

Lee PW  et al. The characteristics, biodistribution, magnetic resonance imaging and biodegradability of superparamagnetic core-shell nanoparticles. Biomaterials 31:1316-24 (2010).

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Llarena M  et al. Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6. Traffic 11:48-69 (2010).

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Colle MA  et al. Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate. Hum Mol Genet 19:147-58 (2010).

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Cites NBP2-22217

Bhandari D, Trejo J, Benovic JL, Marchese A. Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem. 2007 Dec 21

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Iwata A, Riley BE, Johnston JA, Kopito RR. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem. 2005 Dec 2

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Zhang Y, Higashide W, Dai S et al. Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1. J Biol Chem. 2005 Nov 18

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Kunzli BM, Berberat PO, Zhu ZW et al. Influences of the lysosomal associated membrane proteins (Lamp-1, Lamp-2) and Mac-2 binding protein (Mac-2-BP) on the prognosis of pancreatic carcinoma. Cancer. 2002 Jan 1

Cites NBP2-22217

Nishino I, Fu J, Tanji et al. Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature. 2000 Aug 24

Rating

Species

Application

Date

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Human

WB

06-Mar-2016

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Rhesus Monkey

WB

13-May-2014

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Human

IHC-P

20-Dec-2012

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Human

WB

20-Dec-2012

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Monkey

ICC/IF

07-Nov-2012

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Human

ICC/IF

21-May-2012

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Human

ICC/IF

17-May-2011

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Human

ICC/IF

23-Mar-2011

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Human

ICC/IF

26-Jul-2010

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Human

ICC

12-Feb-2010

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Monkey

IHC-Fr

14-Jan-2010

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Mouse

WB

08-Dec-2009

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Human

WB

26-Nov-2009

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Human

ICC/IF

11-Apr-2007

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Human

ICC/IF

31-Mar-2006


Please Note: Anti-CD107b Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
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