Anti-CD130 / gp130 Antibody [A14-5C5] (A279598)

Anti-CD130 / gp130 Antibody [A14-5C5]

Mouse monoclonal [A14-5C5] antibody to CD130 / gp130.

This antibody recognises CD130, also known as glycoprotein 130 (gp130) and STAT3. It is a ubiquitously expressed receptor subunit of the IL-6 family of cytokines and plays a role in many biological processes including hematopoiesis, immune response, inflammation, cardiovascular action, and neuronal survival. CD130 also plays a critical role during development with CD130 deficient mice being embryonically lethal as a result of myocardial hypoplasia and defects in hematopoiesis. CD130 is known to bind various cytokines in the IL-6 family, including IL-6, IL-11, IL-27, CT-1, oncostatin M and ciliary neurotrophic factor. Upon activation by these cytokines, various signaling pathways can be initiated including JAK/STAT, MAPK, mTOR, ERK and PI3K/Atk. The purified Mouse anti Human CD130 antibody, clone A14-5C5 (MCA6232GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CD130 antibody, clone E03-3C2 (MCA6233B) as the detection antibody.

ELISA: 1 µg/ml

Human

Sf21 derived recombinant human CD130 (Leu24-Glu619).

Mouse

Monoclonal

A14-5C5

IgG1

Protein G affinity chromatography of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CD130 antibody, clone A14-5C5, recognizes CD130, also known as glycoprotein 130 (gp130) and STAT3. It is a ubiquitously expressed receptor subunit of the IL-6 family of cytokines and plays a role in many biological processes including hematopoiesis, immune response, inflammation, cardiovascular action, and neuronal survival. CD130 also plays a critical role during development with CD130 deficient mice being embryonically lethal as a result of myocardial hypoplasia and defects in hematopoiesis (White & Stephens 2011). CD130 is known to bind various cytokines in the IL-6 family, including IL-6, IL-11, IL-27, CT-1, oncostatin M and ciliary neurotrophic factor (White & Stephens 2011). Upon activation by these cytokines, various signaling pathways can be initiated including JAK/STAT, MAPK, mTOR, ERK and PI3K/Atk (Silver & Hunter 2010). The purified Mouse anti Human CD130 antibody, clone A14-5C5 (MCA6232GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CD130 antibody, clone E03-3C2 (MCA6233B) as the detection antibody.