Anti-CD133 Antibody [PROM/1510] (A314585)

$765

Mouse monoclonal [PROM/1510] antibody to CD133 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-CD133 Antibody [PROM/1510]
Description
Mouse monoclonal [PROM/1510] antibody to CD133.
Specificity
CD133, also known as PROML1 or Prominin, is a stem cell antigen that may be useful for the selection and expansion of hematopoietic cells and may be used as a positive marker for the characterization of trophoblast cell lines. The human CD133 gene maps to chromosome 4p15.32 and encodes an 865 amino acid protein. The CD133 gene codes for a pentaspan transmembrane glycoprotein that is expressed on primitive hematopoietic stem, progenitor, retinoblastoma, hemangioblasts and neural stem cells and developing epithelium. The 5-TM structure includes an extracellular N-terminus, two short intra- cellular loops, two large extracellular loops and an intracellular C-terminus. CD133 is a candidate gene for retinal proteins that are targeted to plasma membrane protrusions. These retinal proteins, including CD133, may influence the shedding of photoreceptive membranes from the terminal end of the outer segments of vertebrate photoreceptors, where they are phagocytosed by the retinal pigment epithelium, and represent candidates for inherited retinal degenerations.
Applications
IHC-P
Positive Control
Human tonsil.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant chimeric PROM1 protein (around Amino Acids 180-380 and aa612-765). This Mab recognizes both glycosylated and non-glycosylated extracellular domains of CD133.
Host
Mouse
Clonality
Monoclonal
Clone ID
PROM/1510
Isotype
IgG2
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
97 kDa. Depending upon glycosylation, the apparent molecular weight on western blots will increase to ~ 120 kDa.
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
AC133, Antigen AC133, CORD12, Hematopoietic stem cell antigen, hProminin, MCDR2, MSTP061, OTTHUMP00000217744, OTTHUMP00000217745, OTTHUMP00000217746, PROM1, PROM1_HUMAN, Prominin I, Prominin like 1, Prominin like protein 1 precursor, Prominin mouse like 1, Prominin-1, Prominin-like protein 1, Prominin1, PROML1, RP41, STGD4
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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