Anti-CD169 Antibody [MOMA-1] (A281243)

Anti-CD169 Antibody [MOMA-1]

Rat anti Mouse CD169, clone MOMA-1 recognizes murine CD169, also known as sialoadhesin or Siglec-1. CD169 is a lectin-like receptor expressed by certain populations of macrophages including marginal zone metallophils of the spleen, subcapsular macrophages of lymph nodes and stromal macrophages in bone marrow (Morris et al. 1991). CD169 is a ~185 kDa sialic acid binding receptor containing 17 immunoglobulin-like domains (Crocker et al. 1992). Expression of CD169 can be induced on macrophages in culture by a serum factor and further modulated by cytokine exposure (McWilliam et al. 1992). Rat anti mouse CD169, clone MOMA-1 has been used for the in vivo depletion of specific macrophage populations (Kraal et al. 1988).

IF, IHC-Fr

Mouse

Stromal (reticular) elements from mouse lymph nodes.

Rat

Monoclonal

MOMA-1

Tissue culture supernatant.

Liquid

Supplied as an aliquot of tissue culture supernatant with < 0.1% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Sialic acid-binding Ig-like lectin 1, Sialoadhesin, Siglec-1, SIGLEC1, SN