Anti-CD37 Antibody [IPO-24] (A250690)

Anti-CD37 Antibody [IPO-24]

Mouse monoclonal [IPO-24] antibody to CD37.

This antibody recognizes a protein of 33-55kDa, identified as CD37 (Workshop V; Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin'' lymphoma (B-NHL).

Functional Studies, Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Spleen cells of a patient with hairy cell leukemia.

Mouse

Monoclonal

IPO-24

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

33-55 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD37 Antibody [IPO-24] - BSA and Azide free (A253870).

CD 37, CD37 antigen, CD37 molecule, CD37_HUMAN, Cell differentiation antigen 37, GP52 40, Leukocyte antigen CD37, Leukocyte surface antigen CD37, MGC120234, Tetraspanin 26, Tetraspanin-26, Tetraspanin26, TSPAN 26, Tspan-26, TSPAN26