Anti-CD46 Antibody [169-1-E4.3] (A249309)

Mouse monoclonal [169-1-E4.3] antibody to CD46 for Flow Cytometry and IF.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-CD46 Antibody [169-1-E4.3]
Description
Mouse monoclonal [169-1-E4.3] antibody to CD46.
Specificity
This antibody recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.
Applications
Flow Cytometry, IF
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reactivity
Human, Baboon
Cross Reactivity
This antibody does not react with Horse.
Immunogen
Stimulated human leukocytes.
Host
Mouse
Clonality
Monoclonal
Clone ID
169-1-E4.3
Isotype
IgG2a
Light Chains
kappa
Conjugate

Unconjugated

Concentration
200 µg/ml
Molecular Weight
52-58 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD46 Antibody [169-1-E4.3] - BSA and Azide free (A252489).
Synonyms
AHUS2, Antigen defined by monoclonal, Antigen identified by monoclonal, CD46 antigen, CD46 antigen complement regulatory protein, CD46 molecule, CD46 molecule complement regulatory protein, Complement membrane cofactor protein, MCP, MCP_HUMAN, Measles virus receptor, Membrane cofactor protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MGC26544, MIC10, TLX, TRA2.10, Trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, Trophoblast lymphocyte cross reactive antigen
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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