This antibody recognises the C-terminal (CT) region of human CD5 like (CD5L), also known as Apoptosis Inhibitor expressed by Macrophages (AIM), and SP alpha. CD5L is a soluble ~38 kDa glycoprotein produced by mature macrophages, and has been shown to support their survival and enhance phagocytic function. CD5L expression is upregulated in response to LXR/RXR heterodimer activation.CD5L has been shown to mediate the survival of macrophages in atherosclerotic plaques.
Applications
WB, IHC-P
Dilutions
WB: 0.5 - 1 µg/ml
Reactivity
Human, Mouse
Immunogen
A peptide corresponding to 13 amino acids near the C-terminus of human CD5L.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
1 mg/ml
Molecular Weight
Approximately 38 kDa in Raji cell lysates.
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Human CD5l antibody detects the C-terminal (CT) region of human CD5 like (CD5L), also known as Apoptosis Inhibitor expressed by Macrophages (AIM), and SP alpha. CD5L is a soluble ~38 kDa glycoprotein produced by mature macrophages, and has been shown to support their survival and enhance phagocytic function. CD5L expression is upregulated in response to LXR/RXR heterodimer activation.CD5L has been shown to mediate the survival of macrophages in atherosclerotic plaques.
Western Blot - Anti-CD5L / CT-2 Antibody (A283039)
Western Blot analysis of whole cell lysates from Raji human Burkitt's lymphoma cells probed with Anti-CD5L / CT-2 Antibody (A283039) at 0.5(A), 1(B) and 2(C) ug/ml.
