Anti-CD64 Antibody [FCGR1A/4950] (A277602)

Anti-CD64 Antibody [FCGR1A/4950]

Mouse monoclonal [FCGR1A/4950] antibody to CD64.

Three different classes of IgG Fc receptors have been described: Fc γ RI (CD64), Fc γ RII (CD32) and Fc γ RIII (CD16). The low affinity receptors, CD64 and CD16, have a putative role in mediating humoral immune responses. CD64 is a surface glycoprotein with high affinity for monomeric IgG, is expressed constitutively on monocytes and macrophages, and can be induced in neutrophils subsequent to IFN-γ stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will co-immunoprecipitate with CD64 subsequent to receptor cross linking.

WB, IHC

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Rheumatoid synovial fluid cells and fibronectin purified human monocytes.

Mouse

Monoclonal

FCGR1A/4950

IgG1

kappa

Unconjugated

Protein A/G chromatography.

43 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-CD64 Antibody [FCGR1A/4950] - BSA and Azide free (A278190).

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