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Anti-CLASP1 Antibody

 
Rat monoclonal (KT66) antibody to CLASP1 from Absea Biotechnology (050801A06).
Overview
Name: Anti-CLASP1 Antibody
Description: Rat monoclonal (KT66) antibody to CLASP1.
Applications: WB, IF
Reactivity: Human
Immunogen: Recombinant CLASP1 (aa1256 - aa1538).
Amino Acid Start: 177
Amino Acid End: 420
Host: Rat
Clonality: Monoclonal
Clone: KT66
Isotype: IgG2a
Conjugate: Unconjugated
Purification: Antibody is purified from culture supernatant using a protein G column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target
Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Sequence Similarities: Belongs to the CLASP family.
Cellular Location: Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Chromosome > Centromere > Kinetochore. Cytoplasm > Cytoskeleton > Spindle. Golgi apparatus > trans-Golgi network.

Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
UniProt: Q7Z460
Gene ID: 23332
Synonyms: 1700030C23Rik Antibody
5730583A19Rik Antibody
B130045P17Rik Antibody
CLAP1_HUMAN Antibody
CLIP associating protein 1 Antibody
CLIP associating protein CLASP1 Antibody
CLIP-associating protein 1 Antibody
Cytoplasmic linker associated protein 1 Antibody
Cytoplasmic linker-associated protein 1 Antibody
DKFZp686D1968 Antibody
DKFZp686H2039 Antibody
FLJ33821 Antibody
FLJ41222 Antibody
hOrbit1 Antibody
KIAA0622 Antibody
MAST1 Antibody
MGC131895 Antibody
mKIAA0622 Antibody
Multiple asters 1 Antibody
Multiple asters homolog 1 Antibody
Protein Orbit homolog 1 Antibody
Information: Target information shown above is from the UniProt Consortium.

Specific Citations

Nakamura S et al. Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells. PLoS One 7(12): e51442 (2012)

Maffini S et al. Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux. Curr. Biol. 19(18): 1566-1572 (2009)



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Product Citations (1)
Description: Rat monoclonal (KT67) antibody to CLASP1.
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Description: Rabbit polyclonal antibody to CLASP1
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Please Note: Anti-CLASP1 Antibody is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | 050801A06
Size Price Quantity
100µg £186
200µg £273
1mg £730

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