Rat monoclonal (KT66) antibody to CLASP1 from Absea Biotechnology (050801A06).
|Description:||Rat monoclonal (KT66) antibody to CLASP1.|
|Immunogen:||Recombinant CLASP1 (aa1256 - aa1538).|
|Amino Acid Start:||177|
|Amino Acid End:||420|
|Purification:||Antibody is purified from culture supernatant using a protein G column.|
|Concentration:||1 mg/ml in PBS containing 0.09% sodium azide as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.|
|Sequence Similarities:||Belongs to the CLASP family.|
|Cellular Location:||Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Chromosome > Centromere > Kinetochore. Cytoplasm > Cytoskeleton > Spindle. Golgi apparatus > trans-Golgi network.
Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
CLIP associating protein 1 Antibody
CLIP associating protein CLASP1 Antibody
CLIP-associating protein 1 Antibody
Cytoplasmic linker associated protein 1 Antibody
Cytoplasmic linker-associated protein 1 Antibody
Multiple asters 1 Antibody
Multiple asters homolog 1 Antibody
Protein Orbit homolog 1 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Please Note: Anti-CLASP1 Antibody is for research use only. It is not intended for diagnostic of therapeutic use.