Rat monoclonal (KT69) antibody to CLASP2 from Absea Biotechnology (032012H02).
|Description:||Rat monoclonal (KT69) antibody to CLASP2.|
|Immunogen:||Recombinant CLASP2 (90 - 876 bp in KIAA0627).|
|Amino Acid Start:||177|
|Amino Acid End:||420|
|Purification:||Antibody is purified from culture supernatant using a protein G column.|
|Concentration:||1 mg/ml in PBS containing 0.09% sodium azide as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.|
|Sequence Similarities:||Belongs to the CLASP family.|
|Post-Translational Modification:||Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding (PubMed:26003921). Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella.|
|Cellular Location:||Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Chromosome > Centromere > Kinetochore. Cytoplasm > Cytoskeleton > Spindle. Golgi apparatus. Golgi apparatus > trans-Golgi network. Cell membrane. Cell projection > Ruffle membrane.
Localizes to microtubule plus ends (PubMed:15631994). Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase (PubMed:16866869, PubMed:16914514). In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2 (PubMed:16824950). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane.
CLASP 2 Antibody
CLIP associated protein 2 Antibody
CLIP associating protein 2 Antibody
CLIP-associating protein 2 Antibody
Cytoplasmic linker associated protein 2 Antibody
Cytoplasmic linker-associated protein 2 Antibody
Multiple asters (Mast) like homolog 2 Antibody
Protein Orbit homolog 2 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Please Note: Anti-CLASP2 Antibody is for research use only. It is not intended for diagnostic of therapeutic use.