Recombinant Anti-Claudin18 Antibody [CLDN18.2/8559R] (A314794)

Anti-Claudin18 Antibody [CLDN18.2/8559R]

Recombinant rabbit monoclonal [CLDN18.2/8559R] antibody to Claudin18.

The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, occludin and junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Emerging evidence suggests that the claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions.

Concentrated at the cell-cell borders of epithelial cells.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-100) of human Claudin18.2 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

CLDN18.2/8559R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

27.8 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Claudin 18, Claudin-18, CLD18_HUMAN, CLDN18, SFTA5, SFTPJ